, 1994). CoVs genomic RNA replication is mediated by RNA-directed RNA polymerase (Pol/RdRp) which can be also liable for transcription with the viral RNA genome. There may be experimental proof for SARS-CoV that nsp7 and nsp8 activate and confer processivity towards the RNA-synthesizing exercise in the polymerase (Walls et al., 2000). The synthesis
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